阿托伐他汀联合氯吡格雷治疗TIA的临床效果分析(1)
【摘要】 目的 分析阿托伐他汀联合氯吡格雷治疗短暂性脑缺血发作(TIA)的临床效果。方法 96例TIA患者， 应用随机数字表法分为研究组和对照组， 各48例。对照组患者单独应用氯吡格雷进行治疗；研究组患者联合氯吡格雷与阿托伐他汀钙片进行治疗。使用生化分析仪对患者的血脂四项[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]、凝血功能指标[包括凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和血小板(PLT)]进行测定， 对比不良心血管事件发生率。结果 治疗后， 研究组患者的TG、TC、LDL-C等血脂指标明显低于对照组， HDL-C明显高于对照组， 差异具有统计学意义(P<0.05)。两组患者的凝血时间指标比较差异无统计学意义(P>0.05)。研究组患者的不良心血管事件发生率为4.17%， 低于对照组的18.75%， 差异具有统计学意义(P<0.05)。研究组患者不良反应发生率为12.50%， 对照组患者不良反应发生率为6.25%， 两组比较差异无统计学意义(P>0.05)。结论 阿托伐他汀联合氯吡格雷治疗TIA能够调整血脂水平、预防心血管不良事件的发生， 效果对比单独使用氯吡格雷明显更好， 具有较高的应用价值。
【关键词】 阿托伐他汀；氯吡格雷；短暂性脑缺血发作；临床疗效
【Abstract】 Objective To analyze the clinical effect of atorvastatin combined with clopidogrel in the treatment of transient ischemic attack (TIA). Methods A total of 96 TIA patients were divided by random number table method into research group and control group， with 48 cases in each group. The control group received clopidogrel alone for treatment， and the research group received atorvastatin combined with clopidogrel for treatment. Determination were made on four items of blood lipid tests [triglyceride (TG)， total cholesterol (TC)， high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C)]， blood coagulative function index [including prothrombin time (PT)， activated partial thromboplastin time (APTT) and platelet (PLT)]by biochemical analyzer and incidence of adverse cardiovascular events was compared. Results After treatment， the research group had obviously lower TG， TC， LDL-C and higher HDL-C than the control group， and the difference had statistical significance (P<0.05). Both groups had no statistically significant difference in blood coagulation time (P>0.05). The research group had lower incidence of adverse cardiovascular events as 4.17% than 18.75% in the control group， and the difference had statistical significance (P<0.05). The research group had incidence of adverse reactions as 12.50%， while the control group had incidence of adverse reactions as 6.25%， and the difference had statistical significance (P>0.05). Conclusion Combination of atorvastatin and clopidogrel can adjust the blood lipid level， prevent the occurrence of cardiovascular adverse events， and it shows better effect compared with clopidogrel alone. So this method has high application value.
【Key words】 Atorvastatin； Clopidogrel； Transient ischemic attack； Clinical curative effect
TIA屬于常见的心脑血管病症， 好发于颈动脉以及椎基底动脉， 主要原因在于动脉血管发生短暂性血液供应不足进而出现局灶性脑组织血液灌注异常， 引发可逆性或者突发性的神经功能障碍。临床研究发现， TIA属于缺血性脑卒中最为常见的风险因素之一， 给予TIA患者针对性的治疗是降低患者死亡率、预防脑梗死等并发症发生的重要手段。有资料报道， TIA患者不采取治疗的情况下， 发展成为脑梗死的可能性高达33.33%[1]， 1年内缺血性脑卒中的可能性也明显上升。本文中， 对研究组TIA患者给予阿托伐他汀联合氯吡格雷治疗， 结果提示研究组的血脂改善水平更好、不良心血管事件发生率更低， 具有更高的应用价值， 现将方法和结果报告如下。, http://www.100md.com(袁勇)
【关键词】 阿托伐他汀；氯吡格雷；短暂性脑缺血发作；临床疗效
【Abstract】 Objective To analyze the clinical effect of atorvastatin combined with clopidogrel in the treatment of transient ischemic attack (TIA). Methods A total of 96 TIA patients were divided by random number table method into research group and control group， with 48 cases in each group. The control group received clopidogrel alone for treatment， and the research group received atorvastatin combined with clopidogrel for treatment. Determination were made on four items of blood lipid tests [triglyceride (TG)， total cholesterol (TC)， high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C)]， blood coagulative function index [including prothrombin time (PT)， activated partial thromboplastin time (APTT) and platelet (PLT)]by biochemical analyzer and incidence of adverse cardiovascular events was compared. Results After treatment， the research group had obviously lower TG， TC， LDL-C and higher HDL-C than the control group， and the difference had statistical significance (P<0.05). Both groups had no statistically significant difference in blood coagulation time (P>0.05). The research group had lower incidence of adverse cardiovascular events as 4.17% than 18.75% in the control group， and the difference had statistical significance (P<0.05). The research group had incidence of adverse reactions as 12.50%， while the control group had incidence of adverse reactions as 6.25%， and the difference had statistical significance (P>0.05). Conclusion Combination of atorvastatin and clopidogrel can adjust the blood lipid level， prevent the occurrence of cardiovascular adverse events， and it shows better effect compared with clopidogrel alone. So this method has high application value.
【Key words】 Atorvastatin； Clopidogrel； Transient ischemic attack； Clinical curative effect
TIA屬于常见的心脑血管病症， 好发于颈动脉以及椎基底动脉， 主要原因在于动脉血管发生短暂性血液供应不足进而出现局灶性脑组织血液灌注异常， 引发可逆性或者突发性的神经功能障碍。临床研究发现， TIA属于缺血性脑卒中最为常见的风险因素之一， 给予TIA患者针对性的治疗是降低患者死亡率、预防脑梗死等并发症发生的重要手段。有资料报道， TIA患者不采取治疗的情况下， 发展成为脑梗死的可能性高达33.33%[1]， 1年内缺血性脑卒中的可能性也明显上升。本文中， 对研究组TIA患者给予阿托伐他汀联合氯吡格雷治疗， 结果提示研究组的血脂改善水平更好、不良心血管事件发生率更低， 具有更高的应用价值， 现将方法和结果报告如下。, http://www.100md.com(袁勇)